Palladium-catalyzed benzylic C(sp3)–H carbonylative arylation of azaarylmethyl amines with aryl bromides-Reference-Cited by-同舟云学术

Palladium-catalyzed benzylic C(sp3)–H carbonylative arylation of azaarylmethyl amines with aryl bromides

Published:2021 Issue:32 Volume:12 Page:10862-10870
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhao Haoqiang¹²,Hu Bowen¹,Xu Lijin²^ORCID,Walsh Patrick J.¹^ORCID

Affiliation:

1. Roy and Diana Vagelos Laboratories, Penn/Merck Laboratory for High-Throughput Experimentation, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA

2. Department of Chemistry, Renmin University of China, Beijing 100872, China

Abstract

Introduced is a method for the deprotonative carbonylation of azaarylmethyl amines with aryl bromides. The reaction employs a Pd(NIXANTPHOS)-based catalyst and takes place under 1 atm CO.

Funder

National Science Foundation

China Scholarship Council

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02078A

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1. A New Family of Small Molecules To Probe the Reactivation of Mutant p53