Synthesis of 7-amino-6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: a way forward for targeting hypoxia and drug resistance of cancer cells-Reference-Cited by-同舟云学术

Synthesis of 7-amino-6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: a way forward for targeting hypoxia and drug resistance of cancer cells

Published:2021 Issue:61 Volume:11 Page:38782-38795
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Buravchenko Galina I.¹²,Scherbakov Alexander M.³^ORCID,Dezhenkova Lyubov G.¹,Monzote Lianet⁴,Shchekotikhin Andrey E.¹^ORCID

Affiliation:

1. Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia

2. Mendeleyev University of Chemical Technology, 9 Miusskaya Square, Moscow 125190, Russia

3. Blokhin National Medical Research Center of Oncology, 24 Kashirskoye Sh., Moscow 115522, Russia

4. Department of Parasitology, Pedro Kouri Tropical Medicine Institute, Havana, Cuba

Abstract

New water-soluble hypoxia activated 7-aminoquinoxaline 1,4-dioxides, prepared by the regioselective Beirut reaction, acted as HIF-1α suppressors and induced apoptosis in hypoxic and MDR cancer cells.

Funder

Russian Foundation for Basic Research

Ministerio de Ciencia, Tecnología y Medio Ambiente

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA07978F

Reference47 articles.

1. The impact of O2 availability on human cancer

2. Hypoxia and the extracellular matrix: drivers of tumour metastasis

3. Impact of the physical microenvironment on tumor progression and metastasis

4. Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

5. Targeting hypoxia in cancer therapy

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