A high-throughput targeted metabolomics method for the quantification of 104 non-polar metabolites in cholesterol, eicosanoid, and phospholipid metabolism: application in the study of a CCl4-induced liver injury mouse model

Author:

Jia Mengqi1234,Peng Zhangxiao56784,Yang Kaige1234,Su Changqing56784,Wang Yan1234ORCID,Yan Chao1234

Affiliation:

1. School of Pharmacy

2. Shanghai Jiao Tong University

3. Shanghai

4. China

5. Department of Molecular Oncology

6. Eastern Hepatobiliary Surgical Hospital & National Centre for Liver Cancer

7. Second Military Medical University

8. Shanghai 200438

Abstract

Experimental workflow of 104 non-polar metabolites in cholesterol, eicosanoid, and phospholipid metabolisms analysis using UPLC-QqQ-MS.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference46 articles.

1. Metabolomics: the apogee of the omics trilogy

2. Metabonomics

3. O. Fiehn , in Functional genomics , Springer , 2002 , pp. 155–171

4. The metabolomic window into hepatobiliary disease

5. Y. Cai and Z.-J.Zhu , in Microbial Metabolomics , Springer , 2019 , pp. 263–274

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