Broad-spectrum antitumor properties of Withaferin A: a proteomic perspective-Reference-Cited by-同舟云学术

Broad-spectrum antitumor properties of Withaferin A: a proteomic perspective

Published:2020 Issue:1 Volume:11 Page:30-50
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Dom Martin¹²³⁴⁵^ORCID,Vanden Berghe Wim¹²³⁴⁵,Van Ostade Xaveer¹²³⁴⁵

Affiliation:

1. Laboratory of Protein Chemistry

2. Proteomics and Epigenetic Signalling (PPES)

3. Department of Biomedical Sciences

4. University of Antwerp (UA)

5. 2610 Wilrijk

Abstract

A review discussing the broad-spectrum antitumor properties of the natural steroid Withaferin A based on the binding with its true cancer protein targets: a defined stress dependent and stress independent mode of action.

Funder

Fonds Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00296K

Reference152 articles.

1. Molecular insight in the multifunctional activities of Withaferin A

2. Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone

3. The Tumor Inhibitor and Antiangiogenic Agent Withaferin A Targets the Intermediate Filament Protein Vimentin

4. Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies

5. Redox signaling during hypoxia in mammalian cells

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