On the role of helper lipids in lipid nanoparticle formulations of siRNA-Reference-Cited by-同舟云学术

On the role of helper lipids in lipid nanoparticle formulations of siRNA

Published:2019 Issue:45 Volume:11 Page:21733-21739
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Kulkarni Jayesh A.¹²³⁴⁵^ORCID,Witzigmann Dominik¹²³⁴^ORCID,Leung Jerry¹²³⁴,Tam Yuen Yi C.¹²³⁴,Cullis Pieter R.¹²³⁴⁶^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology

2. University of British Columbia

3. Vancouver

4. Canada

5. Department of Medical Genetics

6. NanoMedicines Innovation Network (NMIN)

Abstract

In empty LNP formulations, DSPC–cholesterol resides in outer layers, whereas in loaded systems some of the DSPC–cholesterol is internalized together with siRNA.

Funder

Canadian Institutes of Health Research

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Networks of Centres of Excellence of Canada

British Columbia Innovation Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NR/C9NR09347H

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