Discovery of phosphotyrosine-binding oligopeptides with supramolecular target selectivity

Author:

Pina Ana S.123ORCID,Morgado Leonor23ORCID,Duncan Krystyna L.14,Carvalho Sara23ORCID,Carvalho Henrique F.23ORCID,Barbosa Arménio J. M.23ORCID,de P. Mariz Beatriz23,Moreira Inês P.23,Kalafatovic Daniela1,Morais Faustino Bruno M.5ORCID,Narang Vishal1,Wang Tong16,Pappas Charalampos G.14ORCID,Ferreira Isabel5ORCID,Roque A. Cecília A.23ORCID,Ulijn Rein V.178ORCID

Affiliation:

1. Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York (CUNY), NY 10031, USA

2. Associate Laboratory i4HB – Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal

3. UCIBIO – Applied Molecular Biosciences Unit, Department of Chemistry, School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal

4. Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK

5. CENIMAT/I3N, Department of Materials Science, School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal

6. Imaging Facility of CUNY ASRC, 85 St Nicholas Terrace, New York 10031, USA

7. Hunter College of CUNY, Department of Chemistry and Biochemistry, 695 Park Avenue, New York 10065, USA

8. PhD Programs in Chemistry and Biochemistry, The Graduate Center of CUNY, New York 10016, USA

Abstract

Phage-display screening on self-assembled tyrosine-phosphate ligands enables the identification of oligopeptides selective to dynamic supramolecular targets, with the lead peptide showing a preferred hairpin-like conformation and catalytic activity.

Funder

Royal Society of Chemistry

Air Force Office of Scientific Research

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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