Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy

Published:2021 Issue:3 Volume:12 Page:406-409
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Sasaki Koichi¹²³⁴⁵^ORCID,Muguruma Kyohei⁶⁷⁸⁵,Osawa Rento⁶⁷⁸⁵,Fukuda Akane⁶⁷⁸⁵,Taniguchi Atsuhiko⁶⁷⁸⁵^ORCID,Kishimura Akihiro¹²³⁴⁵,Hayashi Yoshio⁶⁷⁸⁵^ORCID,Mori Takeshi¹²³⁴⁵^ORCID,Katayama Yoshiki¹²³⁴⁵^ORCID

Affiliation:

1. Department of Applied Chemistry

2. Graduate School of Engineering

3. Kyushu University

4. Fukuoka 819-0395

5. Japan

6. Department of Medicinal Chemistry

7. Tokyo University of Pharmacy and Life Sciences

8. Tokyo 192-0392

Abstract

A monocyclic Fc-binding peptide “15-Lys8Leu” enables simple preparation of a Fc-binding antibody-recruiting molecule (Fc-ARM), which induces potent cytotoxicity against folate receptor positive cancer cells via NK cell-mediated immune response.

Funder

Japan Society for the Promotion of Science

Kyushu University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00337A

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