Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy
Author:
Affiliation:
1. Department of Applied Chemistry
2. Graduate School of Engineering
3. Kyushu University
4. Fukuoka 819-0395
5. Japan
6. Department of Medicinal Chemistry
7. Tokyo University of Pharmacy and Life Sciences
8. Tokyo 192-0392
Abstract
A monocyclic Fc-binding peptide “15-Lys8Leu” enables simple preparation of a Fc-binding antibody-recruiting molecule (Fc-ARM), which induces potent cytotoxicity against folate receptor positive cancer cells via NK cell-mediated immune response.
Funder
Japan Society for the Promotion of Science
Kyushu University
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00337A
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