Palladium catalyzed direct allylation of azlactones with simple allylic alcohols in the absence of any activators

Author:

Zhou Hui12345,Yang Huameng1234,Yin Hongyu1234,Liu Muwen12345,Xia Chungu1234,Jiang Gaoxi12346

Affiliation:

1. State Key Laboratory for Oxo Synthesis and Selective Oxidation

2. Lanzhou Institute of Chemical Physics

3. Chinese Academy of Sciences

4. Lanzhou, China

5. Graduate University of Chinese Academy of Sciences

6. Suzhou Institute of Nano-Tech and Nano-Bionics

Abstract

The first example of the readily scalable direct allylic alkylation of azlactones with simple allylic alcohols has been developed, which is catalyzed by Pd(PPh3)4 alone in the absence of any activators under neutral conditions.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference50 articles.

1. J. Tsuji , Transition Metal Reagents and Catalysts , Wiley , New York , 2000

2. Asymmetric Transition-Metal-Catalyzed Allylic Alkylations:  Applications in Total Synthesis

3. Palladium Catalyzed Allylic Alkylations of Nonstabilized Enolates

4. W. Zhang and D.Liu , in Chiral Ferrocenes in Asymmetric Catalysis: Synthesis and Applications , ed. L.-X. Dai and X.-L. Hou , Wiley-VCH : Weinheim , 2010 , ch. 14

5. Biaryl Phosphites: New Efficient Adaptative Ligands for Pd-Catalyzed Asymmetric Allylic Substitution Reactions

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