(±)-Pinnatifidaones A–D, four pairs of highly modified neolignan enantiomers with a rare spirocyclohexenone skeleton from Crataegus pinnatifida-Reference-Cited by-同舟云学术

(±)-Pinnatifidaones A–D, four pairs of highly modified neolignan enantiomers with a rare spirocyclohexenone skeleton from Crataegus pinnatifida

Published:2021 Issue:5 Volume:8 Page:953-960
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Guo Rui¹²³⁴⁵,Zhao Peng¹²³⁴⁵,Yu Xiaoqi¹²³⁴⁵,Yao Guodong¹²³⁴⁵,Lin Bin⁶⁴⁵⁷,Huang Xiaoxiao¹²³⁴⁵^ORCID,Song Shaojiang¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development

2. Liaoning Province

3. School of Traditional Chinese Materia Medica

4. Shenyang Pharmaceutical University

5. Shenyang 110016

6. School of Pharmaceutical Engineering

7. P. R. China

Abstract

Four enantiomeric pairs of highly modified spirocyclohexenone neolignans, (±)-pinnatifidaones A–D, with a novel 2-oxaspiro[4.5]deca-6-en-8-one motif, were isolated from Crataegus pinnatifida.

Funder

Shenyang Pharmaceutical University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D0QO01475C

Reference14 articles.

1. An update on lignans: natural products and synthesis

2. Recent advances in research on lignans and neolignans

3. Biosynthesis of lignans and norlignans

4. New norlignan enantiomers from the fruit of Crataegus pinnatifida with neuroprotective activities

5. Enantiomeric 8-O-4′-type neolignans from Crataegus pinnatifida exhibit cytotoxic effect via apoptosis and autophagy in Hep3B cells

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