Design and synthesis of lipid-coupled inositol 1,2,3,4,5,6-hexakisphosphate derivatives exhibiting high-affinity binding for the HIV-1 MA domain-Reference-Cited by-同舟云学术

Design and synthesis of lipid-coupled inositol 1,2,3,4,5,6-hexakisphosphate derivatives exhibiting high-affinity binding for the HIV-1 MA domain

Author:

Tateishi Hiroshi¹²³⁴,Anraku Kensaku⁵⁶⁷,Koga Ryoko¹²³⁴,Okamoto Yoshinari¹²³⁴,Fujita Mikako⁸⁹³⁴,Otsuka Masami¹²³⁴

Affiliation:

1. Department of Bioorganic Medicinal Chemistry

2. Faculty of Life Sciences

3. Kumamoto University

4. Chuo-ku, Japan

5. Department of Medical Technology

6. Kumamoto Health Science University

7. Kita-ku, Japan

8. Research Institute for Drug Discovery

9. School of Pharmacy

Abstract

Lipid-coupled inositol 1,2,3,4,5,6-hexakisphosphate binds to HIV-1 MA tightly through both electrostatic and hydrophobic interactions.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

Reference26 articles.

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