Metabolomics profiling of methamphetamine addicted human serum and three rat brain areas

Author:

Lin Ming12345ORCID,Xu Jiamin12345,Liu Xi12345,Dai Zhenfeng12345,Liu Zhimin6234,Zhao Xin12345,Sun Yi12345,Pu Xiaoping12345

Affiliation:

1. National Key Research Laboratory of Natural and Biomimetic Drugs

2. Peking University

3. Beijing

4. China

5. Department of Molecular and Cellular Pharmacology

6. National Institute on Drug Dependence

Abstract

To explore the mechanism of METH addiction, the metabolomics profiling of METH addicted human serum and rat brain were performed using UHPLC-MS/MS and MALDI-MSI, respectively. 35 differentially expressed metabolites were identified in the serum.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference53 articles.

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3. Methamphetamine use causes cognitive impairment and altered decision-making

4. J. R.Richards , A.Waheed and E. G.Laurin , in StatPearls , StatPearls Publishing LLC , Treasure Island (FL) , 2019

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