Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents-Reference-Cited by-同舟云学术

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

Published:2020 Issue:6 Volume:44 Page:2247-2255
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Zhou Qifan¹²³⁴⁵,Jia Lina⁶³⁴⁵,Du Fangyu¹²³⁴⁵,Dong Xiaoyu⁶³⁴⁵,Sun Wanyu⁶³⁴⁵,Wang Lihui⁶³⁴⁵,Chen Guoliang¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education

2. School of Pharmaceutical Engineering

3. Shenyang Pharmaceutical University

4. Shenyang 110016

5. P. R. China

6. Department of Pharmacology

Abstract

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining within vitrobiological activity assay and docking results.

Funder

Natural Science Foundation of Liaoning Province

National Natural Science Foundation of China

Scientific Research Fund of Liaoning Provincial Education Department

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/C9NJ04713A

Reference33 articles.

1. Hallmarks of Cancer: The Next Generation