The impact of macrophage-cancer cell interaction on the efficacy of photodynamic therapy-Reference-Cited by-同舟云学术

The impact of macrophage-cancer cell interaction on the efficacy of photodynamic therapy

Published:2015 Issue:8 Volume:14 Page:1403-1409
ISSN:1474-905X
Container-title:Photochemical & Photobiological Sciences
language:en
Short-container-title:Photochem. Photobiol. Sci.

Author:

Korbelik Mladen¹²³,Hamblin Michael R.⁴⁵⁶⁷⁸

Affiliation:

1. British Columbia Cancer Agency

2. Vancouver BC

3. Canada

4. Wellman Center for Photomedicine

5. Massachusetts General Hospital

6. Boston MA

7. USA

8. Department of Dermatology

Abstract

PDT has different effects on macrophages in tumors. The photosensitizer (PS) is taken up by M2 TAMS inside the tumor, which are killed upon light delivery. Signaling from these dying cells attracts new M1 macrophages from the circulation that can kill remaining tumor cells and stimulate an adaptive immune response.

Funder

Canadian Cancer Society Research Institute

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/PP/C4PP00451E

Reference67 articles.

1. The Janus Face of Macrophages in Immunity

2. M1 and M2 Macrophages: The Chicken and the Egg of Immunity

3. Protective and pathogenic functions of macrophage subsets