Stereochemical course of cobalamin-dependent radical SAM methylation by TokK and ThnK
Author:
Affiliation:
1. Department of Chemistry, The Johns Hopkins University, 3400 N Charles St, Baltimore, Maryland, USA
Abstract
Funder
National Institute of Allergy and Infectious Diseases
National Institute of General Medical Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00113F
Reference43 articles.
1. Methylations in complex carbapenem biosynthesis are catalyzed by a single cobalamin-dependent radicalS-adenosylmethionine enzyme
2. Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis
3. Biosynthesis of the beta-lactam antibiotic, thienamycin, by Streptomyces cattleya.
4. Asparenomycins A, B and C, new carbapenem antibiotics. II. Isolation and chemical characterization.
5. Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis
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1. B12-dependent radical SAM enzymes: Ever expanding structural and mechanistic diversity;Current Opinion in Structural Biology;2023-12
2. Changing Fates of the Substrate Radicals Generated in the Active Sites of the B12-Dependent Radical SAM Enzymes OxsB and AlsB;Journal of the American Chemical Society;2023-01-31
3. Sequential C−H Methylation Catalyzed by the B 12 ‐Dependent SAM Enzyme TokK: Comprehensive Theoretical Study of Selectivities;Chemistry – A European Journal;2022-12-09
4. Mechanism of S-Adenosyl-l-methionine C-Methylation by Cobalamin-dependent Radical S-Adenosyl-l-methionine Methylase in 1-Amino-2-methylcyclopropanecarboxylic Acid Biosynthesis;Organic Letters;2022-12-02
5. Structure and Catalytic Mechanism of Radical SAM Methylases;Life;2022-10-28
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