Insights into the thioamidation of thiopeptins to enhance the understanding of the biosynthetic logic of thioamide-containing thiopeptides
Author:
Affiliation:
1. State Key Laboratory of Bioorganic and Natural Products Chemistry
2. Center for Excellence on Molecular Synthesis
3. Shanghai Institute of Organic Chemistry
4. University of Chinese Academy of Sciences
5. Shanghai 200032
Abstract
In vivo experiments show that the thioamide moiety of thiopeptins is generated by a TfuA–YcaO pair, before the maturation of the bicyclic scaffold.
Funder
National Natural Science Foundation of China
Chinese Academy of Sciences
Science and Technology Commission of Shanghai Municipality
China Postdoctoral Science Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00402E
Reference46 articles.
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3. Structure of an EF-Tu Complex with a Thiazolyl Peptide Antibiotic Determined at 2.35 Å Resolution: Atomic Basis for GE2270A Inhibition of EF-Tu,
4. Cooperative Interactions of RNA and Thiostrepton Antibiotic with Two Domains of Ribosomal Protein L11
5. Identification of a Chemical Inhibitor of the Oncogenic Transcription Factor Forkhead Box M1
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