Core–multi-shell design: unlocking multimodal capabilities in lanthanide-based nanoparticles as upconverting, T2-weighted MRI and CT probes

Author:

Liu Nan1ORCID,Homann Christian1ORCID,Morfin Samuel2,Kesanakurti Meghana S.1,Calvert Nicholas D.13,Shuhendler Adam J.134ORCID,Al Tom2,Hemmer Eva1ORCID

Affiliation:

1. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada

2. Department of Earth and Environmental Sciences, University of Ottawa, Ottawa, ON, Canada

3. University of Ottawa Heart Institute, Ottawa, ON, Canada

4. Department of Biology, University of Ottawa, Ottawa, ON, Canada

Abstract

Core/shell/shell nanoparticle design with a controlled inner NaGdF4 layer between the upconverting Er/Yb-doped NaGdF4 core and the magnetic NaDyF4 shell suppressed Dy3+-induced emission loss, while simultaneously enhancing MRI T2 and CT performance.

Funder

University of Ottawa

Canada Foundation for Innovation

China Scholarship Council

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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