Increasing protein stability by engineering the n → π* interaction at the β-turn-Reference-Cited by-同舟云学术

Increasing protein stability by engineering the n → π* interaction at the β-turn

Published:2020 Issue:35 Volume:11 Page:9480-9487
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Khatri Bhavesh¹²³⁴^ORCID,Majumder Puja¹²³⁴^ORCID,Nagesh Jayashree⁵²⁶⁴^ORCID,Penmatsa Aravind¹²³⁴^ORCID,Chatterjee Jayanta¹²³⁴^ORCID

Affiliation:

1. Molecular Biophysics Unit

2. Indian Institute of Science

3. Bangalore 560012

4. India

5. Solid State and Structural Chemistry Unit

6. Bangalore

Abstract

Amino acid residues adopt a right-handed α-helical conformation with increasing strength of the n → π* interaction. We also demonstrate a direct consequence of n → π* interactions on enhancing the structural stability of proteins.

Funder

Science and Engineering Research Board

Ministry of Human Resource Development

University Grants Commission

Department of Biotechnology, Ministry of Science and Technology, India

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC03060K

Reference73 articles.

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4. The Occurence of C–H · · · O Hydrogen Bonds in Proteins

5. A prevalent intraresidue hydrogen bond stabilizes proteins

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