2-Amino-4-aryl thiazole: a promising scaffold identified as a potent 5-LOX inhibitor-Reference-Cited by-同舟云学术

2-Amino-4-aryl thiazole: a promising scaffold identified as a potent 5-LOX inhibitor

Published:2016 Issue:23 Volume:6 Page:19271-19279
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sinha Shweta¹²³⁴⁵,Sravanthi T. V.⁵⁶⁷⁴,Yuvaraj S.⁵⁶⁷⁴,Manju S. L.⁵⁶⁷⁴,Doble Mukesh¹²³⁴

Affiliation:

1. Department of Biotechnology

2. Indian Institute of Technology

3. Madras

4. India

5. Department of Chemistry

6. Vellore Institute of Technology

7. Vellore

Abstract

Human 5-lipoxygenase (5-LOX) is a target for asthma and allergy treatment. Zileuton is the only marketed drug targeting this enzyme (IC₅₀ ∼ 1 μM). The current study identifies a promising lead molecule which could be improved to match the activity of zileuton.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA28187C

Reference60 articles.

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2. Corticosteroids: the mainstay in asthma therapy

3. Leukocyte navigation mechanisms as targets in airway diseases

4. Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease

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