Multifaceted mutational immunotherapeutic approach to design therapeutic mAbs to combat monkeypox disease <i>via</i> integrated screening algorithms and antibody engineering-Reference-Cited by-同舟云学术

Multifaceted mutational immunotherapeutic approach to design therapeutic mAbs to combat monkeypox disease via integrated screening algorithms and antibody engineering

Published:2023 Issue:10 Volume:8 Page:1301-1318
ISSN:2058-9689
Container-title:Molecular Systems Design & Engineering
language:en
Short-container-title:Mol. Syst. Des. Eng.

Author:

Singh Satyendra¹^ORCID,Rao Abhishek¹^ORCID,Mishra Anshuman²,Mishra Amit³,Prajapati Vijay Kumar¹⁴^ORCID

Affiliation:

1. Department of Biochemistry, School of Life Sciences, Central University of Rajasthan, Bandarsindri, Kishangarh, Ajmer, 305817, Rajasthan, India

2. Institute of Advanced Materials IAAM, Gammalkilsvägen 18, Ulrika 59053, Sweden

3. Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, 342037, Rajasthan, India

4. Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, Dhaula Kuan, New Delhi-110021, India

Abstract

Development of therapeutic mAbs against the monkeypox virus targeting critical enzymes. The mutational immunotherapy improves the efficacy. This study provides potential therapy, emphasizing the advantages of mAbs over small molecule inhibitors.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/ME/D3ME00059A

Reference73 articles.

1. European Center for Disease Control , Epidemiological update: monkeypox outbreak , Available at: https://www.ecdc.europa.eu/en/news-events/epidemiological-update-monkeypox-outbreak , Accessed May 31 2022

2. World Health Organization , Multi-country monkeypox outbreak: situation update , Available at: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON392 , Accessed June 15 2022

3. A POX-LIKE DISEASE IN CYNOMOLGUS MONKEYS

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