Hierarchical dynamics in allostery following ATP hydrolysis monitored by single molecule FRET measurements and MD simulations-Reference-Cited by-同舟云学术

Hierarchical dynamics in allostery following ATP hydrolysis monitored by single molecule FRET measurements and MD simulations

Published:2021 Issue:9 Volume:12 Page:3350-3359
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wolf Steffen¹²³⁴⁵^ORCID,Sohmen Benedikt⁶³⁴⁵^ORCID,Hellenkamp Björn⁷⁸⁹¹⁰,Thurn Johann⁶³⁴⁵,Stock Gerhard¹²³⁴⁵^ORCID,Hugel Thorsten⁶³⁴⁵¹¹^ORCID

Affiliation:

1. Biomolecular Dynamics

2. Institute of Physics

3. University of Freiburg

4. Freiburg

5. Germany

6. Institute of Physical Chemistry

7. Engineering and Applied Sciences

8. Columbia University

9. New York

10. USA

11. Signalling Research Centers BIOSS and CIBSS

Abstract

We report on a study that combines advanced fluorescence methods with molecular dynamics simulations to cover timescales from nanoseconds to milliseconds for a large protein, the chaperone Hsp90.

Funder

Freiburg Institute for Advanced Studies, Albert-Ludwigs-Universität Freiburg

H2020 European Research Council

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC06134D

Reference58 articles.

1. Allostery in Its Many Disguises: From Theory to Applications

2. Symmetry, Rigidity, and Allosteric Signaling: From Monomeric Proteins to Molecular Machines

3. Kinetic response of a photoperturbed allosteric protein

4. Time-resolved observation of protein allosteric communication

5. Real-time observation of ligand-induced allosteric transitions in a PDZ domain

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