High-throughput optofluidic screening for improved microbial cell factories via real-time micron-scale productivity monitoring-Reference-Cited by-同舟云学术

High-throughput optofluidic screening for improved microbial cell factories via real-time micron-scale productivity monitoring

Published:2021 Issue:15 Volume:21 Page:2901-2912
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Rienzo Matthew¹²³⁴^ORCID,Lin Ke-Chih⁵⁶³⁴^ORCID,Mobilia Kellen C.⁵⁶³⁴,Sackmann Eric K.⁵⁶³⁴,Kurz Volker⁵⁶³⁴,Navidi Adam H.¹²³⁴,King Jarett¹²³⁴,Onorato Robert M.⁵⁶³⁴,Chao Lawrence K.¹²³⁴,Wu Tony¹²³⁴,Jiang Hanxiao¹²³⁴,Valley Justin K.¹²³⁴,Lionberger Troy A.⁵⁶³⁴,Leavell Michael D.¹²³⁴

Affiliation:

1. Research and Development

2. Amyris, Inc.

3. Emeryville

4. USA

5. Technology and Business Development

6. Berkeley Lights, Inc.

Abstract

We describe high-throughput (>10³ strains per week) methods for discovery of engineered microbial strains with improved secretion phenotype. These novel approaches use real-time monitoring of colony productivity under steady-state or batch culture.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D1LC00389E

Reference31 articles.

1. Engineering Cellular Metabolism

2. Metabolic Engineering: Past and Future

3. Clean manufacturing powered by biology: how Amyris has deployed technology and aims to do it better

4. Development of a commercial scale process for production of 1,4-butanediol from sugar

5. Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals

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