Bacteria-targeted delivery of black phosphorus quantum dots facilitates photothermal therapy against hypoxic tumors and complementary low-dose radiotherapy

Author:

Ji Pengchao123,Chen Jinghua2,Wang Hao134,Shi Linfei5,Tang Xudong16ORCID,Duo Yanhong176

Affiliation:

1. Key Lab for New Drug Research of TCM, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong, China

2. Department of Medical Oncology, Shenzhen People's Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of the Southern University of Science and Technology), Shenzhen 518020, China

3. Guangdong Engineering Technological Research Center for Nervous Anatomy and Related Clinical Applications, Shenzhen People's Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of the Southern University of Science and Technology), Shenzhen 518020, Guangdong, China

4. Department of neurosurgery, Shenzhen People's Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of the Southern University of Science and Technology), Shenzhen 518020, Guangdong, China

5. Qing Hai Center for Diseases Prevention and Control, Xining 810007, Qinghai, China

6. State Key Laboratory of Fine Chemicals, Department of Pharmacology, School of Chemical Engineering, Dalian University of Technology, Dalian, China

7. Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden

Abstract

Many approaches have been employed to relieve hypoxia in solid tumors to enhance sensitivity to radiotherapy (RT), including O2 delivery or hydrogen peroxide (H2O2) decomposition strategies.

Funder

Science, Technology and Innovation Commission of Shenzhen Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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