A fluorescent target-guided Paal–Knorr reaction
Author:
Affiliation:
1. The Department of Chemistry and Biochemistry
2. Texas State University
3. San Marcos 78666
4. USA
5. Xenobe Research Institute
6. San Diego
Abstract
A pocket-templated Paal–Knorr reaction delivers fluorescent COX-2 probes.
Funder
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA06962K
Reference25 articles.
1. Templated chemistry for bioorganic synthesis and chemical biology
2. Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery
3. Kinetic target-guided synthesis
4. Chemistry of Ketene N,S-Acetals: An Overview
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2. Medicinal chemical optimization of fluorescent pyrrole-based COX-2 probes;Tetrahedron;2022-09
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