Chemoselective synthesis of 5,4′-imidazolinyl spirobarbiturates via NBS-promoted cyclization of unsaturated barbiturates and amidines-Reference-Cited by-同舟云学术

Chemoselective synthesis of 5,4′-imidazolinyl spirobarbiturates via NBS-promoted cyclization of unsaturated barbiturates and amidines

Published:2021 Issue:22 Volume:19 Page:4978-4985
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Xu Hui¹²³⁴⁵^ORCID,Huang Rong-Lu¹²³⁴⁵,Shu Zhu¹²³⁴⁵,Hong Ran¹²³⁴⁵,Zhang Ze¹²³⁴⁵^ORCID

Affiliation:

1. Anhui Province Key Laboratory of Functional Coordinated Complexes for Materials Chemistry Application

2. and School of Chemical and Environmental Engineering

3. Anhui Polytechnic University

4. Wuhu 241000

5. P. R. China

Abstract

The cyclization of unsaturated barbiturates and amidines promoted by N-bromosuccinimide furnished a variety of structurally novel 5,4′-imidazolinyl spirobarbiturates with high chemoselectivity, good yields and remarkable functional group tolerance.

Funder

Natural Science Foundation of Anhui Province

University Natural Science Research Project of Anhui Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00508A

Reference36 articles.

1. Selective Reduction of Barbituric Acids Using SmI2/H2O: Synthesis, Reactivity, and Structural Analysis of Tetrahedral Adducts

2. The Clinical Use of Barbiturates in Neurological Disorders