Oxidation of free, peptide and protein tryptophan residues mediated by AAPH-derived free radicals: role of alkoxyl and peroxyl radicals-Reference-Cited by-同舟云学术

Oxidation of free, peptide and protein tryptophan residues mediated by AAPH-derived free radicals: role of alkoxyl and peroxyl radicals

Published:2016 Issue:63 Volume:6 Page:57948-57955
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Fuentes-Lemus E.¹²³⁴⁵,Dorta E.¹²³⁴⁵,Escobar E.¹²³⁴⁵,Aspée A.⁶⁷⁴⁵,Pino E.⁶⁷⁴⁵,Abasq M. L.⁸⁹¹⁰¹¹,Speisky H.¹²¹³¹⁴⁵,Silva E.¹⁵²³⁴⁵,Lissi E.⁶⁷⁴⁵,Davies M. J.¹⁶¹⁷¹⁸¹⁹,López-Alarcón C.¹²³⁴⁵

Affiliation:

1. Departamento de Farmacia

2. Facultad de Química

3. Pontificia Universidad Católica de Chile

4. Santiago

5. Chile

6. Facultad de Química y Biología

7. Universidad de Santiago de Chile

8. Faculté de Sciences Pharmaceutiques et Biologiques

9. Université de Rennes 1

10. Rennes

11. France

12. Instituto de Nutrición y Tecnología de los Alimentos

13. INTA

14. Universidad de Chile

15. Departamento de Química Física

16. Department of Biomedical Sciences

17. Panum Institute

18. University of Copenhagen

19. Denmark

Abstract

When AAPH is employed as a free radical source, at low concentrations of free, peptide and protein Trp residues, the oxidation is mostly induced by alkoxyl radicals. However, at high concentrations, both peroxyl and alkoxyl radicals are involved.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA12859A

Reference34 articles.

1. Selective Formation of Oxindole- and Formylkynurenine-Type Products from Tryptophan and Its Peptides Treated with a Superoxide-Generating System in the Presence of Iron(III)-EDTA: A Possible Involvement with Iron-Oxygen Complex

2. OXIDATION OF FREE AMINO ACIDS AND AMINO ACID RESIDUES IN PROTEINS BY RADIOLYSIS AND BY METAL-CATALYZED REACTIONS

3. The oxidative environment and protein damage

4. The reaction of oxygen with radicals from oxidation of tryptophan and indole-3-acetic acid

5. Kinetics and mechanism of the chemiluminescence associated with the free radical-mediated oxidation of amino acids

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