Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity-Reference-Cited by-同舟云学术

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

Published:2015 Issue:8 Volume:44 Page:3614-3623
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Nazarov Alexey A.¹²³⁴⁵,Meier Samuel M.⁶⁷⁸⁹,Zava Olivier¹²³⁴,Nosova Yulia N.⁵¹⁰¹¹,Milaeva Elena R.⁵¹⁰¹¹,Hartinger Christian G.¹²¹³¹⁴¹⁵,Dyson Paul J.¹²³⁴

Affiliation:

1. Institute of Chemical Sciences and Engineering

2. Swiss Federal Institute of Technology (EPFL)

3. Lausanne

4. Switzerland

5. M. V. Lomonosov Moscow State University

6. University of Vienna

7. Institute of Analytical Chemistry

8. 1090 Vienna

9. Austria

10. 119991 Moscow

11. Russia

12. University of Auckland

13. School of Chemical Sciences

14. Auckland 1142

15. New Zealand

Abstract

The conjugation of chlorambucil to the RAPTA scaffold results in an anticancer active agent capable of cross-linking DNA and proteins.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/DT/C4DT02764G

Reference42 articles.

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2. World Health Organization

3. Celebrating the New

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