A stimuli-responsive polymer modified nanopore for measuring β-amyloid peptide and zinc ions in brains of live mice with Alzheimer's disease-Reference-Cited by-同舟云学术

A stimuli-responsive polymer modified nanopore for measuring β-amyloid peptide and zinc ions in brains of live mice with Alzheimer's disease

Published:2023 Issue:4 Volume:2 Page:851-857
ISSN:2635-0998
Container-title:Sensors & Diagnostics
language:en
Short-container-title:Sens. Diagn.

Author:

Ding Shushu¹²^ORCID,Zhu Yue¹,Zhu Anwei²^ORCID,Shi Guoyue²^ORCID

Affiliation:

1. School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, People's Republic of China

2. School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, 500 Dongchuan Road, Shanghai 200241, People's Republic of China

Abstract

A copolymer-modified glass nanopore combined with microdialysis was used for assaying cerebral Aβ monomer and Zn2+. In the presence of Aβ monomer, the copolymer stretched. Then, the Zn2+ altered surface charges and fluorescence.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SD/D2SD00228K

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