Macrolactam analogues of macrolide natural products-Reference-Cited by-同舟云学术

Macrolactam analogues of macrolide natural products

Published:2016 Issue:48 Volume:14 Page:11301-11316
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hügel Helmut M.¹²³⁴,Smith Andrew T.⁵⁶⁷⁴,Rizzacasa Mark A.⁸⁹¹⁰⁴

Affiliation:

1. School of Science & Biomedical and Health Innovations Enabling Capability Platform

2. RMIT University

3. Melbourne

4. Australia

5. Griffith Sciences

6. Gold Coast campus

7. Griffith University

8. School of Chemistry

9. the Bio21 Institute

10. The University of Melbourne

Abstract

The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity.

Funder

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB02149B

Reference71 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

3. What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

4. Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

5. The exploration of macrocycles for drug discovery — an underexploited structural class

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