An optimized procedure for direct access to 1H-indazole-3-carboxaldehyde derivatives by nitrosation of indoles-Reference-Cited by-同舟云学术

An optimized procedure for direct access to 1H-indazole-3-carboxaldehyde derivatives by nitrosation of indoles

Published:2018 Issue:24 Volume:8 Page:13121-13128
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Chevalier Arnaud¹²³⁴⁵,Ouahrouch Abdelaaziz¹²³⁴⁵^ORCID,Arnaud Alexandre¹²³⁴⁵,Gallavardin Thibault¹²³⁴⁵^ORCID,Franck Xavier¹²³⁴⁵^ORCID

Affiliation:

1. Normandie Univ

2. CNRS

3. UNIROUEN

4. INSA Rouen

5. COBRA (UMR 6014 and FR 3038)

Abstract

The nitrosation of indoles under slightly acidic conditions and reverse addition conditions leads to the preparation of the corresponding indazole-3-carboxaldehydes in high yields and greatly minimizes side reactions.

Funder

Institut National des Sciences Appliquées Rouen

Université de Rouen

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA01546E

Reference41 articles.

1. Isolation and structure determination of nigellicine, a novel alkaloid from the seeds of

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4. Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

5. Synthesis of indazole motifs and their medicinal importance: An overview

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