An explicitly designed paratope of amyloid-β prevents neuronal apoptosis in vitro and hippocampal damage in rat brain-Reference-Cited by-同舟云学术

An explicitly designed paratope of amyloid-β prevents neuronal apoptosis in vitro and hippocampal damage in rat brain

Published:2021 Issue:8 Volume:12 Page:2853-2862
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Paul Ashim¹²³⁴⁵^ORCID,Kumar Sourav⁶⁷⁸⁹⁵,Kalita Sujan¹²³⁴⁵,Kalita Sourav¹²³⁴⁵,Sarkar Dibakar¹⁰¹¹¹²¹³⁵,Bhunia Anirban¹⁰¹¹¹²¹³⁵^ORCID,Bandyopadhyay Anupam¹⁴²¹⁵¹⁶⁵^ORCID,Mondal Amal Chandra⁶⁷⁸⁹⁵^ORCID,Mandal Bhubaneswar¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Peptide and Amyloid Research

2. Department of Chemistry

3. Indian Institute of Technology Guwahati (IITG)

4. North Guwahati

5. India

6. Neuroscience Research Unit

7. Department of Physiology

8. Raja Peary Mohan College

9. Uttarpara

10. Biomolecular NMR and Drug Design Laboratory

11. Department of Biophysics

12. Bose Institute

13. Kolkata 700054

14. Peptide Engineering Laboratory

15. Indian Institute of Technology

16. Ropar

Abstract

Herein, the therapeutic potentials of an explicitly designed peptide probe are systematically illuminated in vitro and in vivo against Aβ aggregation. The probe demonstrates remarkable potency for attenuating neurotoxicity and hippocampal damage.

Funder

Department of Biotechnology, Ministry of Science and Technology

University Grants Commission

Bose Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC04379F

Reference68 articles.

1. The amyloid state and its association with protein misfolding diseases