1,2,4-Triazolo[4,3-c]quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

1,2,4-Triazolo[4,3-c]quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity

Published:2021 Issue:25 Volume:45 Page:11136-11152
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

El-Shershaby Mohamed H.¹²³⁴⁵,Ghiaty Adel¹²³⁴⁵,Bayoumi Ashraf H.¹²³⁴⁵,Ahmed Hany E. A.¹²³⁴⁵,El-Zoghbi Mona S.⁶⁷⁸⁵,El-Adl Khaled⁹³⁴⁵¹⁰^ORCID,Abulkhair Hamada S.¹²³⁴⁵^ORCID

Affiliation:

1. Pharmaceutical Organic Chemistry Department

2. Faculty of Pharmacy

3. Al-Azhar University

4. Cairo

5. Egypt

6. Pharmaceutical Chemistry Department, Faculty of Pharmacy

7. Menoufia University

8. Shebin El-Koum

9. Department of Medicinal Chemistry & Drug Design, Faculty of Pharmacy

10. Department of Pharmaceutical Chemistry

Abstract

Targeting PCAF with small inhibitor molecules has emerged as a potential therapeutic strategy for the treatment of cancer.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ00710F

Reference52 articles.

1. Histone Modifications and Cancer

2. Histone Modifications and their Role in Colorectal Cancer (Review)

3. Keep-ING balance: Tumor suppression by epigenetic regulation

4. The bromodomain interaction module

5. Bromodomains as therapeutic targets

Cited by 36 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Efficient synthesis and molecular docking analysis of quinazoline and azole hybrid derivatives as promising agents for anti-cancer and anti-tuberculosis activities;Journal of Molecular Structure;2024-08

2. Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers;Bioorganic Chemistry;2024-03

3. Novel Benzochromenes: Design, Synthesis, Cytotoxicity, Molecular Docking and Mechanistic Investigations;Future Medicinal Chemistry;2024-01

4. Crystallography and Anti-Cancer Evaluation of Triazoloquinazolinone: Hirshfeld Surface Analysis, Dft Modeling, Admet Studies, and Molecular Docking;2024

5. PIFA Mediated Synthesis of Bis‐1,2,4‐triazoloquinazolines as Potential Anticancer Agents on MCF‐7 Cancer Cells: Characterization, Molecular Docking, Antiproliferative and ADME Profile;ChemistrySelect;2023-12-21

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3