Ribosomal translation of fluorinated non-canonical amino acids for <i>de novo</i> biologically active fluorinated macrocyclic peptides-Reference-Cited by-同舟云学术

Ribosomal translation of fluorinated non-canonical amino acids for de novo biologically active fluorinated macrocyclic peptides

Published:2024 Issue:34 Volume:15 Page:13889-13898
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wu Junjie¹,Wang Yuchan²,Cai Wenfeng¹,Chen Danyan²,Peng Xiangda³,Dong Huilei⁴,Li Jinjing⁴,Liu Hongtan⁴,Shi Shuting²,Tang Sen²,Li Zhifeng¹,Sui Haiyan¹,Wang Yan²,Wu Chuanliu⁴^ORCID,Zhang Youming¹,Fu Xinmiao²,Yin Yizhen¹⁵^ORCID

Affiliation:

1. State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China

2. College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China

3. Shanghai Zelixir Biotech Company Ltd, Shanghai 200030, China

4. College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China

5. Shandong Research Institute of Industrial Technology, Jinan 250101, China

Abstract

Fluorinated non-canonical amino acids were ribosomally translated, allowing identification of fluorinated macrocyclic peptides with strong binding to EphA2 and broad-spectrum activity against Gram-negative bacteria by targeting the BAM complex.

Funder

National Natural Science Foundation of China

Shandong University

Taishan Scholar Project of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC04061A

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