Preclinical evaluation of platinum-loaded hydroxyapatite nanoparticles in an embryonic zebrafish xenograft model-Reference-Cited by-同舟云学术

Preclinical evaluation of platinum-loaded hydroxyapatite nanoparticles in an embryonic zebrafish xenograft model

Published:2020 Issue:25 Volume:12 Page:13582-13594
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Nadar Robin A.¹²³⁴⁵^ORCID,Asokan Nandini⁶⁷⁸⁹¹⁰^ORCID,Degli Esposti Lorenzo¹¹¹²¹³¹⁴^ORCID,Curci Alessandra¹⁵¹⁶¹⁷¹⁴^ORCID,Barbanente Alessandra¹⁵¹⁶¹⁷¹⁴^ORCID,Schlatt Lukas¹⁸¹⁹²⁰⁹,Karst Uwe¹⁸¹⁹²⁰⁹^ORCID,Iafisco Michele¹¹¹²¹³¹⁴^ORCID,Margiotta Nicola¹⁵¹⁶¹⁷¹⁴^ORCID,Brand Michael⁶⁷⁸⁹^ORCID,van den Beucken Jeroen J. J. P.¹²³⁴⁵^ORCID,Bornhäuser Martin⁶⁷⁸⁹¹⁰^ORCID,Leeuwenburgh Sander C. G.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Dentistry - Regenerative Biomaterials

2. Radboud Institute for Molecular Life Sciences

3. Radboud University Medical Center

4. 6525 EX Nijmegen

5. the Netherlands

6. Center for Regenerative Therapies Dresden (CRTD)

7. Technische Universität Dresden

8. 01307 Dresden

9. Germany

10. Division of Hematology

11. Institute of Science and Technology for Ceramics (ISTEC)

12. National Research Council (CNR)

13. 48018 Faenza

14. Italy

15. Dipartimento di Chimica

16. Università degli Studi di Bari Aldo Moro

17. 70125 Bari

18. Institute of Inorganic and Analytical Chemistry

19. University of Münster

20. 48149 Münster

Abstract

Kiteplatin-pyrophosphate (PtPP) loaded hydroxyapatite nanoparticles effectively reduce breast cancer cell in vivo, which opens up new opportunities for controlled local treatment of bone metastases.

Funder

Radboud Universitair Medisch Centrum

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR04064A

Reference59 articles.

1. Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

2. Development of nanomaterials for bone-targeted drug delivery

3. Surface properties of biomimetic nanocrystalline apatites; applications in biomaterials

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