Enhancing the correlation between in vitro and in vivo experiments in dental implant osseointegration: investigating the role of Ca ions

Author:

Romero Gavilán Francisco1ORCID,Cerqueira Andreia1ORCID,Anitua Eduardo234,Muñoz Fernando5,García Arnáez Iñaki6,Azkargorta Mikel7,Elortza Félix7,Gurruchaga Mariló6ORCID,Goñi Isabel6,Suay Julio1,Tejero Ricardo23ORCID

Affiliation:

1. Department of Industrial Systems Engineering and Design, Universitat Jaume I, Av. Vicent Sos Baynat s/n, 12071 Castellón de la Plana, Spain

2. BTI Biotechnology Institute I + D, C/Leonardo da Vinci 14B, Miñano 01510, Spain

3. University Institute of Regenerative Medicine and Oral Implantology (UIRMI), University of the Basque Country (UPV/EHU), C/Jacinto Quincoces, 39, Vitoria 01007, Spain

4. Private Practice in Oral Implantology, C/Jose Maria Cagigal, 19, Vitoria 01007, Spain

5. Facultade de Veterinaria, Universidade de Santiago de Compostela, Campus Universitario, s/n, Lugo 27002, Spain

6. Facultad de Ciencias Químicas, Universidad del País Vasco, P. M. de Lardizábal, 3, San Sebastián 20018, Spain

7. Proteomics Platform, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), CIBERehd, Bizkaia Science and Technology Park, Derio 48160, Spain

Abstract

This study explores the osteogenic potential of unicCa implants via advanced proteomics. Enhanced cell adhesion, osteogenic functions and diminished immune response were found to correlate under both in vitro and in vivo conditions.

Funder

Generalitat Valenciana

Universitat Jaume I

Publisher

Royal Society of Chemistry (RSC)

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