Thiourea derivatives containing 4-arylthiazoles and <scp>d</scp>-glucose moiety: design, synthesis, antimicrobial activity evaluation, and molecular docking/dynamics simulations-Reference-Cited by-同舟云学术

Thiourea derivatives containing 4-arylthiazoles and d-glucose moiety: design, synthesis, antimicrobial activity evaluation, and molecular docking/dynamics simulations

Published:2023 Issue:6 Volume:14 Page:1114-1130
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Thanh Nguyen Dinh¹^ORCID,Lan Pham Hong¹²,Hai Do Son¹²,Anh Hoang Huu¹,Giang Nguyen Thi Kim¹²,Van Hoang Thi Kim¹³,Toan Vu Ngoc¹⁴,Tri Nguyen Minh¹⁴,Toan Duong Ngoc¹⁵

Affiliation:

1. Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Ha Noi, Vietnam

2. Institute of Science and Technology, Ministry of Public Security of Vietnam, 47 Pham Van Dong, Cau Giay, Ha Noi, Vietnam

3. Faculty of Chemical Technology, Viet Tri University of Industry, Tien Kien, Lam Thao, Phu Tho, Vietnam

4. Institute of New Technology, Military Institute of Science and Technology (Ministry of Military), 17 Hoang Sam, Cau Giay, Ha Noi, Vietnam

5. Faculty of Chemistry, Thai Nguyen University of Education, 20 Luong Ngoc Quyen, Thai Nguyen, Vietnam

Abstract

Substituted thioureas with 1,3-thiazole and d-glucose were gained from 2-amino-1,3-thiazoles and glucopyranosyl isocyanate. They had antimicrobial activity, some inhibiting S. aureus DNA gyrase, DNA Topo IV, and dihydrofolate reductase. IFD, MM-GBSA and MD were performed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00010A

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