<i>Gastrodia elata</i> polysaccharide alleviates Parkinson's disease <i>via</i> inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota-Reference-Cited by-同舟云学术

Gastrodia elata polysaccharide alleviates Parkinson's disease via inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota

Published:2024 Issue:6 Volume:15 Page:2920-2938
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Gan Qing-xia¹²,Peng Mao-yao¹²,Wei Hao-bo¹²,Chen Lin-lin¹²,Chen Xiao-yan¹²,Li Zi-han¹²,An Guang-qin¹²,Ma Yun-tong¹²^ORCID

Affiliation:

1. College of Pharmacy, Chengdu University of Traditional Chinese, Medicine, No.1166, Liutai Road, Wenjiang District, Chengdu, 611137, China

2. State Key Laboratory of Traditional Chinese Medicine Processing Technology, State Administration of Traditional Chinese Medicine, No.1166, Liutai Road, Wenjiang District, Chengdu, 611137, China

Abstract

Gastrodia elata polysaccharide significantly alleviated motor dysfunction, inhibited α-synuclein accumulation in PD mice via inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota.

Funder

Department of Science and Technology of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO05169B

Reference104 articles.

1. New hope for Parkinson's disease treatment: Targeting gut microbiota

2. Natural history of motor symptoms in Parkinson’s disease and the long-duration response to levodopa

3. Mass spectrometry imaging identifies abnormally elevated brain l -DOPA levels and extrastriatal monoaminergic dysregulation in l -DOPA–induced dyskinesia

4. A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease

5. L-Theanine alleviates MPTP-induced Parkinson's disease by targeting Wnt/β-catenin signaling mediated by the MAPK signaling pathway

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