Polyclonal aptamer libraries as binding entities on a graphene FET based biosensor for the discrimination of apo- and holo-retinol binding protein 4-Reference-Cited by-同舟云学术

Polyclonal aptamer libraries as binding entities on a graphene FET based biosensor for the discrimination of apo- and holo-retinol binding protein 4

Published:2022 Issue:7 Volume:7 Page:770-778
ISSN:2055-6756
Container-title:Nanoscale Horizons
language:en
Short-container-title:Nanoscale Horiz.

Author:

Kissmann Ann-Kathrin¹,Andersson Jakob²,Bozdogan Anil²³,Amann Valerie¹,Krämer Markus¹,Xing Hu¹,Raber Heinz Fabian¹,Kubiczek Dennis H.¹,Aspermair Patrik²^ORCID,Knoll Wolfgang²⁴,Rosenau Frank¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany

2. AIT Austrian Institute of Technology GmbH, Giefinggasse 4, 1210 Vienna, Austria

3. CEST Kompetenzzentrum für Elektrochemische Oberflächentechnologie GmbH, Viktor Kaplan Straße 2, Wiener Neustadt, Austria

4. Danube Private University, Steiner Landstraße 124, 3500 Krems an der Donau, Austria

Abstract

We report a sensor based on polyclonal aptamer libraries which is capable of label-free discrimination between retinol binding protein 4 isoforms (an important biomarker for kidney disease and diabetes) at sub-nM concentrations.

Funder

Baden-Württemberg Stiftung

Horizon 2020 Framework Programme

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NH/D1NH00605C

Reference57 articles.

1. Adipocytokines and Insulin Resistance