Synthesis of multi-substituted 4-aminopyridines via ring-opening and recyclization reactions of 2-iminopyridines

Author:

Zhou Fenguo12345,Zhang Ning123,Xin Xiaoqing123,Zhang Xun123,Liang Yongjiu123,Zhang Rui123,Dong Dewen123

Affiliation:

1. Changchun Institute of Applied Chemistry

2. Chinese Academy of Sciences

3. Changchun 130022, China

4. School of Chemistry and Environmental Engineering

5. Changchun University of Science and Technology

Abstract

Synthesis of multi-substituted 4-aminopyridines is developed via a regioselective ring-opening reaction of 2-iminopyridines followed by a 6π-azaelectrocyclization and N-to-N 1,3-sulfonyl group migration process.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference54 articles.

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2. J. A. J. K. Mills , Heterocyclic Chemistry , Wiley India Pvt. Ltd. , 4th edn, 2008

3. Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition toN-Activated Pyridines

4. De novo synthesis of substituted pyridines

5. Recent Strategies for the Synthesis of Pyridine Derivatives

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