Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation-Reference-Cited by-同舟云学术

Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation

Published:2015 Issue:11 Volume:7 Page:1378-1386
ISSN:1757-9694
Container-title:Integrative Biology
language:en
Short-container-title:Integr. Biol.

Author:

Sumit M.¹²³⁴⁵,Neubig R. R.⁶⁷⁸⁵,Takayama S.¹²³⁴⁵,Linderman J. J.⁹³⁴⁵¹⁰

Affiliation:

1. Biointerface Institute

2. North Campus Research Complex

3. University of Michigan

4. Ann Arbor

5. USA

6. Department of Pharmacology and Toxicology

7. Michigan State University

8. East Lansing

9. Department of Biomedical Engineering

10. Department of Chemical Engineering

Abstract

Pulsatile stimulation of a GPCR pathway reveals that the downstream signal activation is optimized for intermediate frequencies in a band-pass manner that can be explained by the kinetics of the signaling pathway.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Link

http://pubs.rsc.org/en/content/articlepdf/2015/IB/C5IB00181A

Reference51 articles.

1. Encoding and Decoding Cellular Information through Signaling Dynamics

2. Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription

3. Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module

4. Pulsing cells: How fast is too fast?

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