Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the lac repressor-Reference-Cited by-同舟云学术

Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the lac repressor

Published:2020 Issue:37 Volume:11 Page:10175-10179
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

de Geus Mark A. R.¹²³⁴⁵^ORCID,Groenewold G. J. Mirjam¹²³⁴⁵,Maurits Elmer¹²³⁴⁵,Araman Can¹²³⁴⁵^ORCID,van Kasteren Sander I.¹²³⁴⁵^ORCID

Affiliation:

1. Leiden Institute of Chemistry

2. The Institute for Chemical Immunology

3. Leiden University

4. 2333 CC Leiden

5. The Netherlands

Abstract

Two novel reagents were developed to direct formation of allylic cis-cyclooctene (CCO) ethers, followed by photochemical isomerization to obtain trans-cyclooctene (TCO) ethers. The method was used to cage a bio-active carbohydrate.

Funder

Stichting voor de Technische Wetenschappen

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC03216F

Reference42 articles.

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