Enhanced bone regeneration <i>via</i> PHA scaffolds coated with polydopamine-captured BMP2-Reference-Cited by-同舟云学术

Enhanced bone regeneration via PHA scaffolds coated with polydopamine-captured BMP2

Published:2022 Issue:32 Volume:10 Page:6214-6227
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Zhang Xu¹^ORCID,Li Jian²³,Chen Jin⁴,Peng Zi-Xin²³,Chen Jiang-Nan⁴,Liu Xinyi⁴,Wu Fuqing⁴,Zhang Peng²³,Chen Guo-Qiang¹⁴

Affiliation:

1. Key Laboratory of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Tsinghua-Peking Center of Life Sciences, Beijing 100084, China

2. University of Chinese Academy of Sciences, Beijing, 100049, China

3. Shenzhen Engineering Research Center for Medical Bioactive Materials, Center for Translational Medicine Research & Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China

4. School of Life Sciences, Tsinghua University, Tsinghua-Peking Center of Life Sciences, Beijing 100084, China

Abstract

3D-printed scaffolds of polyhydroxyalkanoate (PHA) are functionalized using polydopamine (PDA)-mediated recombinant human bone morphogenetic protein-2 (BMP2) to generate high osteoinductive activity for in vivo bone regeneration.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Horizon 2020 Framework Programme

Shenzhen Institutes of Advanced Technology Innovation Program for Excellent Young Researchers

Tsinghua University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB01122K