Synthesis and anti-tubercular activity of N2-arylbenzo[g]isoquinoline-5,10-dione-3-iminium bromides-Reference-Cited by-同舟云学术

Synthesis and anti-tubercular activity of N2-arylbenzo[g]isoquinoline-5,10-dione-3-iminium bromides

Published:2016 Issue:6 Volume:14 Page:2041-2051
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Rotthier G.¹²³⁴⁵,Cappoen D.⁶⁷⁸⁹¹⁰,Nguyen Quang Trung¹¹¹²¹³¹⁴,Dang Thi Tuyet Anh¹¹¹²¹³¹⁴,Mathys V.¹⁵¹⁶¹⁷¹⁸¹⁹,Nguyen Van Tuyen¹¹¹²¹³¹⁴,Huygen K.²⁰¹⁷¹⁸¹⁹⁵,Maes L.⁶⁷⁸⁹¹⁰,Cos P.⁶⁷⁸⁹¹⁰,Abbaspour Tehrani K.¹²³⁴⁵

Affiliation:

1. Organic Synthesis

2. Faculty of Sciences

3. University of Antwerp

4. B-2020 Antwerp

5. Belgium

6. Laboratory of Microbiology

7. Parasitology and Hygiene (LMPH)

8. S7

9. Faculty of Pharmaceutical

10. Biomedical and Veterinary Sciences

11. Institute of Chemistry

12. Vietnam Academy of Sciences and Technology

13. Cau Giay

14. Vietnam

15. Program Tuberculosis and Mycobacteria

16. Service Bacterial Diseases

17. O.D. Communicable & Infectious Diseases

18. Scientific Institute of Public Health (Site Ukkel)

19. B-1180 Ukkel

20. Scientific Service Immunology

Abstract

The synthesis of a new class of benzo[g]isoquinoline-5,10-diones carrying an amidine functionality and their anti-mycobacterial activities againstMycobacterium tuberculosisH37Rv are reported.

Funder

Fonds Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02138C

Reference34 articles.

1. Straightforward palladium-mediated synthesis and biological evaluation of benzo[j]phenanthridine-7,12-diones as anti-tuberculosis agents

2. Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine

3. 1,2,3,4,8,9,10,11-Octahydrobenzo[j]phenanthridine-7,12-diones as New Leads against Mycobacterium tuberculosis