Anti-bacterial, anti-biofilm and synergistic effects of phenazine-based ruthenium(ii) complexes

Author:

Martins Patrícia H. R.1ORCID,Romo Adolfo I. B.2ORCID,Gouveia Jr. Florêncio S.1ORCID,Paz Iury A.3,Nascimento Nilberto R. F.3,Andrade Alexandre L.4,Rodríguez-López Joaquín2ORCID,de Vasconcelos Mayron A.5ORCID,Teixeira Edson Holanda4ORCID,Moraes Carlos André Ferreira6,Lopes Luiz G. F.1ORCID,Sousa Eduardo Henrique Silva de1ORCID

Affiliation:

1. Bioinorganic Group, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, CE, 60451-970, Brazil

2. Department of Chemistry, University of Illinois at Urbana–Champaign, Urbana, Illinois, 61801, USA

3. Laboratory of Cardiovascular and Renal Physiology and Pharmacology (LAFCAR), State University of Ceará (UECE), Fortaleza, 60714-903, Brazil

4. Biomolecule Integrated Laboratory (LIBS), Federal University of Ceará, Fortaleza, CE, 60451-970, Brazil

5. Faculty of Education of Itapipoca (FACEDI), State University of Ceará, Itapipoca (UECE), Ceará, 62500-000, Brazil

6. Department of Chemistry, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, 13565-905, Brazil

Abstract

A ruthenium complex with DNA-binding capacity and a nitrosyl ligand showed strong antimicrobial activities including anti-biofilm and synergistic effects with antibiotics.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico

Financiadora de Estudos e Projetos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

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