In situ real-time tracing of hierarchical targeting nanostructures in drug resistant tumors using diffuse fluorescence tomography

Author:

Guo Qianqian12345,Wang Yangyun678910,Zhang Limin11121314,Zhang Peng15161718ORCID,Yu Yunjian12345,Zhang Yanqi11121314,Li Chaoxing12345,Jiang Shaoyi15161718,Zhang Xinge12345ORCID

Affiliation:

1. Key Laboratory of Functional Polymer Materials of Ministry of Education

2. Institute of Polymer Chemistry

3. College of Chemistry

4. Nankai University

5. Tianjin 300071

6. State Key Laboratory of Radiation Medicine and Protection

7. School for Radiological & Interdisciplinary Sciences (RAD-X)

8. Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions

9. Soochow University

10. Suzhou 215123

11. College of Precision Instrument and Optoelectronics Engineering

12. Tianjin University

13. Tianjin 300072

14. China

15. Department of Chemical Engineering

16. University of Washington

17. Seattle

18. USA

Abstract

Nanoparticles that respond to specific endogenous or exogenous stimuli in tumor tissues are actively being developed to address multidrug resistance owing to multiple advantages, including a prolonged circulation time, enhanced permeability and retention effect, and superior cellular uptake.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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