Design and synthesis of atorvastatin derivatives with enhanced water solubility, hepatoselectivity and stability-Reference-Cited by-同舟云学术

Design and synthesis of atorvastatin derivatives with enhanced water solubility, hepatoselectivity and stability

Published:2023 Issue:1 Volume:14 Page:56-64
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Maklakova Svetlana Yu.¹^ORCID,Lopukhov Anton V.¹,Khudyakov Alexandr D.¹,Kovalev Sergey V.¹,Mazhuga Maria P.¹,Chepikova Olga E.²,Zamyatnin Andrey A.²³⁴⁵,Majouga Alexander G.¹⁶,Klyachko Natalia L.¹,Beloglazkina Elena K.¹^ORCID

Affiliation:

1. Chemistry Department, Lomonosov Moscow State University, GSP-1, Leninskie Gory 1/3, Moscow 119991, Russian Federation

2. Department of Biotechnology, Sirius University of Science and Technology, Olympic Avenue 1, Sochi 354340, Russian Federation

3. Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Trubetskaya Street 8/2, Moscow 119991, Russian Federation

4. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow 119992, Russian Federation

5. Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK

6. Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya Square 9, Moscow 125047, Russian Federation

Abstract

Atorvastatin conjugates targeting the galactose-specific hepatic asialoglycoprotein receptor with improved stability are reported.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00119E

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