Catalytic asymmetric synthesis of enantioenriched α-deuterated pyrrolidine derivatives-Reference-Cited by-同舟云学术

Catalytic asymmetric synthesis of enantioenriched α-deuterated pyrrolidine derivatives

Published:2022 Issue:14 Volume:13 Page:4041-4049
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chang Xin¹²,Cheng Xiang¹,Wang Chun-Jiang¹²^ORCID

Affiliation:

1. Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China

2. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China

Abstract

A strategy of combining H/D-Ex and azomethine ylide-involved 1,3-DC was developed for the construction of α-deuterated pyrrolidine derivatives in good yields with excellent stereoselectivities and uniformly high levels of deuterium incorporation.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Natural Science Foundation of Hubei Province

Project 211

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC00826B

Reference50 articles.