Anticancer activity of a new copper(ii) complex with a hydrazone ligand. Structural and spectroscopic characterization, computational simulations and cell mechanistic studies on 2D and 3D breast cancer cell models-Reference-Cited by-同舟云学术

Anticancer activity of a new copper(ii) complex with a hydrazone ligand. Structural and spectroscopic characterization, computational simulations and cell mechanistic studies on 2D and 3D breast cancer cell models

Published:2021 Issue:28 Volume:50 Page:9812-9826
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Balsa Lucia M.¹²³⁴⁵,Ferraresi-Curotto Verónica⁶²⁷⁸,Lavecchia Martin J.¹²³⁴⁵,Echeverría Gustavo A.⁶²⁷⁸,Piro Oscar E.⁶²⁷⁸,García-Tojal Javier⁹¹⁰¹¹¹²,Pis-Diez Reinaldo¹²³⁴⁵,González-Baró Ana C.¹²³⁴⁵^ORCID,León Ignacio E.¹²³⁴⁵^ORCID

Affiliation:

1. Centro de Química Inorgánica (CEQUINOR

2. CONICET-UNLP)

3. Facultad de Ciencias Exactas

4. Universidad Nacional de La Plata

5. 1900 La Plata

6. Instituto de Física La Plata (IFLP

7. La Plata

8. Argentina

9. Departamento de Química

10. Universidad de Burgos

11. 09001 Burgos

12. Spain

Abstract

We report here the synthesis, crystal structure, characterization and anticancer activity of a copper(ii)-hydrazone complex, [Cu(MeBHoVa)(H₂O)₂](NO₃) (for short, CuHL), against human breast cancer cells on monolayer (2D) and spheroids/mammospheres (3D).

Funder

Consejo Nacional de Investigaciones Científicas y Técnicas

Universidad Nacional de La Plata

Agencia Nacional de Promoción Científica y Tecnológica

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D1DT00869B

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