Esterification of the free carboxylic group from the lutidinic acid ligand as a tool to improve the cytotoxicity of Ru(ii) complexes-Reference-Cited by-同舟云学术

Esterification of the free carboxylic group from the lutidinic acid ligand as a tool to improve the cytotoxicity of Ru(ii) complexes

Published:2019 Issue:2 Volume:6 Page:376-390
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Honorato João¹²³⁴^ORCID,Colina-Vegas Legna¹²³⁴^ORCID,Correa Rodrigo S.¹⁵⁶⁷⁴,Guedes Adriana P. M.¹²³⁴,Miyata Marcelo⁸⁹¹⁰⁴,Pavan Fernando R.⁸⁹¹⁰⁴,Ellena Javier¹¹¹²³⁴^ORCID,Batista Alzir A.¹²³⁴¹³

Affiliation:

1. Departamento de Química

2. Universidade Federal de São Carlos – UFSCar

3. São Carlos

4. Brazil

5. ICEB

6. Universidade Federal de Ouro Preto – UFOP

7. Ouro Preto MG

8. Faculdade de Ciências Farmacêuticas

9. Universidade Estadual Paulista – UNESP

10. Araraquara

11. Instituto de Física de São Carlos

12. Universidade de São Paulo – USP

13. Instituto de Química

Abstract

The esterification of the free carboxyl group in ruthenium complexes improves the complex interactions with biomolecules, lipophilicity, and cellular uptake, making them more selective against tumor cells than cisplatin.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QI/C8QI00941D

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