Rapid detection of carbapenem-resistant Enterobacteriaceae using pH response based on vancomycin-modified Fe3O4@Au nanoparticle enrichment and the carbapenemase hydrolysis reaction

Author:

Wang Jianmin12345,Yang Wei12345,Peng Qiling6345,Han Daobin12345,Kong Liangsheng12345,Fan Lu12345,Zhao Min12345,Ding Shijia12345ORCID

Affiliation:

1. Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education)

2. College of Laboratory Medicine

3. Chongqing Medical University

4. Chongqing 400016

5. China

6. Chongqing Engineering Research Center for Criminal Investigation Technology

Abstract

Rapid and simple detection of carbapenem-resistant Enterobacteriaceae (CRE) is important to manage infection and prevent the spread of these bacteria.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Chongqing Science and Technology Commission

Chongqing Municipal Education Commission Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Reference38 articles.

1. WHO , Antimicrobial resistance: global report on surveillance , 2014 , http://www.who.int/drugresistance/documents/surveillancereport/en/ (accessed October 2019)

2. WHO , Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa in health care facilities , https://www.who.int/infection-prevention/publications/guidelines-cre/en/ (accessed October 2019)

3. Strategies for identification of carbapenemase-producing Enterobacteriaceae

4. Phenotypic Screening of Carbapenemases and Associated  -Lactamases in Carbapenem-Resistant Enterobacteriaceae

5. Rapid detection of carbapenemase activity of Enterobacteriaceae isolated from positive blood cultures by MALDI-TOF MS

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