Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound-Reference-Cited by-同舟云学术

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound

Published:2017 Issue:7 Volume:8 Page:4756-4763
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Li-Juan¹²³⁴⁵,Wang Wanhe⁶⁷⁸⁵,Huang Shi-Ying⁹¹⁰¹¹⁵¹²,Hong Yanjun¹³⁶⁷⁸¹⁴,Li Guodong¹²³⁴⁵,Lin Sheng⁶⁷⁸⁵,Tian Jinglin¹³⁶⁷⁸¹⁴,Cai Zongwei¹³⁶⁷⁸¹⁴,Wang Hui-Min David¹⁵¹⁶¹⁷^ORCID,Ma Dik-Lung⁶⁷⁸⁵,Leung Chung-Hang¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine

2. Institute of Chinese Medical Sciences

3. University of Macau

4. Macao

5. China

6. Department of Chemistry

7. Hong Kong Baptist University

8. Kowloon Tong

9. College of Oceanology and Food Science

10. Quanzhou Normal University

11. Quanzhou 362000

12. Key Laboratory for the Development of Bioactive Material from Marine Algae

13. Partner State Key Laboratory of Environmental and Biological Analysis

14. P. R. China

15. Graduate Institute of Biomedical Engineering

16. National Chung Hsing University

17. Taiwan

Abstract

This study reports the first use of an iridium(iii) compound and its enantiomer to inhibit the H-Ras/Raf-I PPI in vitro and repress renal cancer xenografts in vivo.

Funder

National Natural Science Foundation of China

Hong Kong Baptist University

Health and Medical Research Fund

Research Grants Council

Natural Science Foundation of Guangdong Province

Science and Technology Development Fund

University of Macau

Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject